10.1017/S0022029900030600
Tunyasuvunakool, K., Adler, J., Wu, Z., Green, T., Zielinski, M., dek, A., Bridgland, A., Cowie, A., Meyer, C., Laydon, A., Velankar, S., Kleywegt, G
& Tack, C
The mode of action for AMG133 is believed to involve this bispecific molecule simultaneously binding to both the GIP- and GLP-1 receptor, where it is demonstrated to increase cAMP production and induce internalization of co-localized GIP and GLP-1 receptors
the pairing is the canonical GHRH + GHRP combination referenced across growth-hormone-secretagogue research literature
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